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• 1 Hoorcollege

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• What do T-cells recognize and where do they recognize it? A. Peptides. B. Receptors. C. Microbes. D. Cytokines. 1. Intracellular. 2. On the surface of their cell. 3. On the surface of the presenting cell. 4. Dependent where it is presented.

  A, 3.

• Open vraag: Where are cytosolic pathogens degraded and to which type of cells are they presented by which MHC? And what is the effect of the presentation?

  In the cytosol, they are presented to CD 8 T-cellls by MHC class I and the effect of the presentation is cell death.

• How are intravesivular pathogens degreded in the endocytic vesicles? Open vraag: Which 2 antigen presenting cells are responsible for this? A. High pH . B. With oxygen radicals.   C. Low pH . D. Phagocytosis .

  C.

  B cells and macrophages.

• What kind of pathogens do B-cells recognize? Open vraag: And where are these pathogens degraded and to which cells are these pathogens presented by which type of MHC? And what is the effect of the presentation? A. Extracellular pathogens. B. Extracellular toxins. C. Intravesicular pathogens. D. Cytosolic pathogens.

  A and B. 

  They are degraded in the endocytic vesicle (low pH). The pathogens are presented to CD4 T-cells on MHC II molecules. The effect of the presenting B cell is activation of B cells to secrete Ig to eliminate extracelular pathogens.

• What is true about the proteasome? A. Major lysosomal degradation system. B. Major non lysosomal degradation system. C. Tagged with ubiquitin. D. Tagged with thymine. E. Cytosolic.

  B,C,E.

• Open vraag: What does TAP do? Where does it interact with?

  Transports peptides in ER. It interacts with tapasin.

• Open vraag: What is tapasin? What does it do, and what does it links together? 

  Tapasin is a chaperon that stabelizes MHC I in the ER. It links MHC I to TAP.

• What happens when MHC I and Tap are linked by tapasin? A. Decrease of peptide translocation. B. Increase of MHC I translocation. C. Increase of peptide translocation. D. Decrease of MHC I translocation.

  C.

• Open vraag: Not all peptides can be bound by a single MHC molecule, how is it possible to present peptides from different microbial proteins?

  MHC genes DO NOT go through genetic recombination.

• Open vraag: The MHC locus is polygenic, what does that mean?

  Multiple genes with the same function.